Amit Kumar Meena
Dermatology, Lady Hardinge Medical College, India
Title: Biochemical and hormonal abnormalities in adult female acne
Biography
Biography: Amit Kumar Meena
Abstract
Statement of the Problem: Prevalence of adult patients with acne is increasing and women comprise majority of the cases. There is lack of data on biochemical and hormonal abnormalities in adult female acne (AFA). The purpose of this study was to evaluate biochemical and hormonal parameters in 60 patients of AFA.
Methodology: A cross-sectional observational study conducted from November 2018 to March 2020 in Dermatology outpatient department of a tertiary care hospital in North India. Adult females (age > 25 years) with a clinical diagnosis of acne were included in the study.
Findings: 60 cases of AFA were included. The age ranged between 26–41 years with mean age at presentation being 29.45 years. 53.3% patients had persistent acne while 46.7% had late-onset acne. 50% patients had historyof premenstrual flare-up of their acne. Raised fasting blood glucose was found in 25% patients. 10% had raised serum insulin levels. HOMA-IR (Homeostasis model assessment of insulin resistance) index was deranged in 55% patients. At least one lipid alteration was reported in 91.6% of patients. In hormonal parameters, raised total testosterone was present in 6.7%, luteinizing hormone in 3.3%, follicle stimulating hormone in 18.3%, prolactin in 3.3%, and thyroid stimulating hormone in 15%. No association was found between acne severity and biochemical and hormonal parameters.
Conclusion & Significance: Our study highlighted the importance of measuring lipid profile in AFA and calculating HOMA-IR index for measuring insulin resistance rather than simply measuring serum insulin levels. In our study, additional parameter deranged in significant number of patients was FBG. Hence, we recommend routine screening of lipid profile, FBG and calculation of HOMA-IR index in AFA.