13^th International Conference on Cosmetology and Dermatology August 21-22, 2023 Dubai, UAE

Biography:

Nasim Tootoonchi is an Assistant professor at Tehran University Of Medical Science, Razi Hospital . working in a specialized referral center helps her to deal with specific and rare manifestations of common inflammatory skin diseases every day, and to keep the passion for treatment and research.
Her expertise and interest in this field has led her to work most of the week in specialized clinics for inflammatory skin diseases  and autoimmune bullous disease.

Abstract:

Worldwide, particularly in developing countries, the population has aged over the past decades.

In each society, a notable financial and healthcare burden will be specified to this age group, because this subgroup suffers from various chronic debilitating diseases such as dermatological conditions. An important issue, regarding the occurrence of psoriasis in the elderly, is unusual clinical manifestations of the disease in this age population. Epidemiological studies could show considerably higher rates of systemic complications such as heart failure, , psoriatic arthritis, as well as poorer quality of life. Accordingly, therapeutic approaches in psoriasis should be different as compared to the younger population. To achieve such a goal, the first step will be to gather sufficient information about the epidemiological, demographic, and clinical features of the disease in each community. Methodology: we aimed to provide an overview of the epidemiological, clinical, and therapeutic consequences among elderly patients with psoriasis in Iranian society. This study was conducted on 156 patients over 60 years with the definitive diagnosis of psoriasis referred to our center between 2015 and 2019. Results and conclusions: Among geriatric psoriasis patients, we determined the male to female ratio of 3 to 2, and the peak age of 67 years. The most common clinical feature is the plaque type and the most frequent involved zone is upper extremities. Among underlying comorbidities, the association of hypertension and diabetes mellitus with psoriasis is more expected than other diseases. In older adults, topical medications are more preferred to systemic approaches. Sex differences in disease characteristics are mainly related to mean age at disease onset, disease duration, plaque type of the disease, and the risk for nail involvement. Further studies are required to determine which drug therapies are more effective and should be prescribed to geriatric psoriatic patients.

Biography:

Amit Kumar Meena did his MBBS from AIIMS Jodhpur and three year post graduate training and 1.5 year senior resident in Lady Hardinge Medical College, Delhi, India. I am currently working as a senior resident in dermatology department in Lady Hardinge Medical College, Delhi, India. I have interest in pediatric dermatology, acne, psoriasis, vitiligo, leprosy and cutaneous Tuberculosis.

Abstract:

Statement of the Problem: Prevalence of adult patients with acne is increasing and women comprise majority of the cases. There is lack of data on biochemical and hormonal abnormalities in adult female acne (AFA). The purpose of this study was to evaluate biochemical and hormonal parameters in 60 patients of AFA.  

Methodology: A cross-sectional observational study conducted from November 2018 to March 2020 in Dermatology outpatient department of a tertiary care hospital in North India. Adult females (age > 25 years) with a clinical diagnosis of acne were included in the study.

Findings:  60 cases of AFA were included. The age ranged between 26–41 years with mean age at presentation being 29.45 years. 53.3% patients had persistent acne while 46.7% had late-onset acne. 50% patients had historyof premenstrual flare-up of their acne. Raised fasting blood glucose was found in 25% patients. 10% had raised serum insulin levels. HOMA-IR (Homeostasis model assessment of insulin resistance) index was deranged in 55% patients. At least one lipid alteration was reported in 91.6% of patients. In hormonal parameters, raised total testosterone was present in 6.7%, luteinizing hormone in 3.3%, follicle stimulating hormone in 18.3%, prolactin in 3.3%, and thyroid stimulating hormone in 15%. No association was found between acne severity and biochemical and hormonal parameters.

Conclusion & Significance: Our study highlighted the importance of measuring lipid profile in AFA and calculating HOMA-IR index for measuring insulin resistance rather than simply measuring serum insulin levels. In our study, additional parameter deranged in significant number of patients was FBG. Hence, we recommend routine screening of lipid profile, FBG and calculation of HOMA-IR index in AFA.

Biography:

Clessya Rocha is an experienced Brazilian certified dermatologist, who over her 17 years of practice has built protocols with minimally invasive technologies and treatments for facial rejuvenation, bringing beauty and naturalness to her patients. Currently, in addition to being a dermatologist, she works as a professor of dermatology at the State University of Southwest Bahia and is a researcher in PDO threads, her doctoral thesis in progress. International speaker, recently published the article on Association of PDO threads and Technologies Facial Treatment protocols.

Abstract:

Aging is part of the human being, and the search for treatments to alleviate facial wrinkles is frequent in the dermatological office, where minimally invasive facial rejuvenation techniques often associate technologies and polydioxanone (PDO) threads that together present satisfactory result. The concern of most medical professionals when using these technologies, which initially heat the skin, is the possibility of breaking or melting the wires. However, it is well established that the melting point of PDO polymer is 110° to 115° C, a temperature well above the maximum temperature reached by thermal damage to tissues caused by technologies. Although there are still no publications on protocols and technologies for associating PDO threads, however, through the scientific evidence already well established by the basic principles of the technologies and their mechanisms of action, interaction with the tissue, it is possible to associate these techniques. A summary of the associations of the most common current technologies with PDO threads can be found in Table 1. Among the technologies, microfocused ultrasound (HIFU) acts in the same anatomical plane as the PDO threads, which is the superficial subcutaneous layer. For contextualization, I report the case of a patient where HIFU and PDO wires with claws were performed and the result after 60 days. 150 shots were performed per hemiface with Ultraformer® technology with the tips: 4.5 - 30 shots 0.8 mj; 3.0 - 30 shots, 0.7 mj; 2.0 - 50 shots 0.3 mj and 1.5 0.2 mj 40 shots. Then, 2 PDO Sculpt® wires 18 G x 165 mm were made in the middle third and 2 PDO spiculated wires 19 G x 160 mm in the lower third per hemiface, totaling 8 (Figure 1). This poster aims to bring clarity on how to use the technology associated with PDO threads.

Biography:

Clinical Officer - Dermato-Venereologist Kenya

Abstract:

Background
The field of cosmetic dermatology has witnessed remarkable advancements with the integration of nanotechnology, offering promising opportunities to enhance the efficacy and safety of cosmetic products and procedures. Nanotechnology, involving manipulating and utilizing materials at the nanoscale level, has paved the way for innovative approaches in skincare and aesthetic treatments. Nanotechnology has revolutionized the formulation and delivery of cosmetic products by enabling the development of nanosized delivery systems. These have been successfully utilized to enhance the stability, penetration, and controlled release of active ingredients in cosmetics. Consequently, nanotechnology has shown promising results in improving skincare products' efficacy, such as anti-aging creams, sunscreens, and skin-lightening agents.

Methods
 The research paper will evaluate different scholarly articles, systematic reviews, and healthcare protocols and frameworks on how nanomaterials have been used in cosmetic dermatology. It also examines the fundamental rules of its use and risk assessment by institutions of higher learning like universities and colleges, government laboratories, and industry players in advancing the field of cosmetic dermatology. Particular focus will be on how the International Organization for Standardization (ISO) has formulated uniform standards for nanotechnology and promoting innovation, research and development, and risk assessment on using nanotechnology in cosmetic dermatology.

Findings
Moreover, nanotechnology has facilitated the development of diagnostic and monitoring tools in cosmetic dermatology. Nanosensors and nanodevices can detect and measure various skin parameters, such as hydration levels, sebum production, and skin pH. These devices offer real-time monitoring and personalized skincare recommendations, contributing to the advancement of precision dermatology.

Conclusions
Nanomaterials in cosmetic dermatology have the potential to transform how cosmetics and drugs deliver their benefits radically. Specifically, nanotechnology in the form of nanoparticles can be developed and applied to encapsulate a broad range of ingredients for the benefit and wellbeing of the skin.

Biography:

Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.

Abstract:

Purpose: In order to evaluate increasing patients' complaints of change in the appearance of melanocytic nevi following hair removal laser, we planned this study to describe dermoscopic changes that happen on acquired junctional melanocytic nevi after using photo-depilation methods.

Method: In this prospective study, 66 melanocytic nevi in 27 patients were chosen. A Dermoscopic image  was taken at first and 3 months after 1 session of hair removal laser. Then the images compared with each other and changes in nevi were noted.

 Results: there were some alterations including changes in size in 33%, color in 63.6%, asymmetry in 12.1%, reticular pattern in 92.5%, dots and globules pattern in 69.32% and regression in 3% of nevi.

 Conclusions: Hair removal laser could induce some changes in appearance of acquired junctional melanocytic nevi. Dermoscopic study before and after the process, could help to avoid unnecessary excision of suspected lesions. 

Keywords: melanocytic nevi, dermoscopic changes, hair removal laser, photoepilation

Introduction:

Increasing demand for rapid and non-invasive depilation lead generating Intense Pulsed Light (IPL) systems, afterward lasers such as Alexandrite, Diode and Nd-Yag Laser (1, 2).

Target of lasers in the hair removal lasers is melanin in hair follicles, an endogenous chromophore that absorbs energy of beats with wavelengths near 600 to 1200 nm, transfers this heat to hair follicle and destroys it. Laser beam would not destroy the epidermal melanin before arriving to its target, hair follicle melanin in dermis, as the ratio of melanocytes to keratinocytes in epidermis is less than hair follicle and epidermal melanocytes contain fewer and smaller melanosomes than those in the hair follicles melanocytes. Furthermore, selecting appropriate wavelengths and wide spot size in addition to using cooling systems helps protection of epidermal melanocytes. Therefore, hair removal laser is considered a safe procedure with minimal epidermal side effects (3).

 Considering the fact that melanocytic nevi composed of numerous heavily melanized melanocytes, these structures could absorb some part of the beat energy at the surface of skin before arriving at melanin of hair follicles in dermis. Therefore, some changes could happen in their appearance when applying these instruments for treating superficial melanocytic lesions. (4, 5)

There are some case reports that show regression or dermoscopic changes in size, pigmentation and pattern of melanocytic nevi after photo-depilation with IPL or laser systems. Furthermore, some of them reported changes of nevi in patients with past personal or family history of dysplastic nevi or malignant melanoma, although histologic changes did not have enough evidence for malignant transformation. (6-12)

In addition to these scattered reports, recently Guicciardi et al evaluated clinical and dermoscopic effects of photoepilation on 73 melanocytic nevi in a prospective study. They noted pigmentation changes and both complete regression and progressive growth but not malignant modification. (13)

As far as we know, there are limited studies about the effect of hair removal lasers on melanocytic nevi in literature review. So we planned this assay in order to help the decision if hair removal laser avoidance in the sites of melanocytic nevi is necessary or not.

Methods and Materials:

Patients

Females referred to Laser Clinic of Razi Dermatology Hospital, Tehran, Iran between October 2018 and October 2019 that supposed to perform a hair removal laser for the first time participated in this cross-sectional study by applying a simple sampling method.  

Methods

 Alexandrite Laser (GENTLEMAX PRO^®755 nm, Candela, Massachusetts, USA, 18 mm spot size, 14-16 mj fluence) was used for hair removal. We examined the skin of candidates to detect junctional melanocytic nevi at the sites of supposing to Laser, if it exists, we assessed it by dermoscope (Fotofinder medicam 1000, Germany) and took photograph and dermoscopic images of it before initiation of Laser. Nearly three months after laser epilation, the same nevi were reanalyzed and dermoscopic images were taken to compare any change in size, color, symmetry, reticulation pattern, dot/globule pattern and regression of nevi before and following the hair removal laser.

Statistical analysis

Chi-Square and Independent T-tests were used to compare qualitative and Quantitative variables, respectively. Two-tailed P-value < 0.05 was considered as statistically significant. SPSS software version 18 was used for all statistical analyses.

 Ethical consideration

All participants filled informed consent and the Ethics Committee of Tehran University of Medical Sciences approved the protocol of study. 

Results:

Twenty-seven women with age of 29.95 ± 5.81 years participated in the study. Sixty-six junctional melanocytic nevi in their bodies were analyzed before the first session of hair removal laser and 3 months after that.  

Fifty-nine nevi (90%) were located on the upper part of the body and seven (10%) on the lower part.

Patients Fitzpatrick skin type was two, three and four in 9 (13.6%), 45 (68.2%) and 12 (18.2%) cases, respectively.

Changes in size:

We observed a decrease in size at least 1 mm in 33% of nevi after hair removal laser, but there was no difference in size in 66%. There was no difference in alteration of size with age, location of nevi and Fitzpatrick skin type, but we detected a significant relation between changes in size and alteration in color (p-value: 0.01), as has been described below. 

Discussion:

Our results revealed that hair removal lasers could induce some changes on acquired junctional melanocytic nevi but none of them showed dermoscopic criteria of malignant transformation. Most changes happened on the reticular and dot/globule patterns in 92.5% and 71.2% of nevi, respectively, Pic(1, 2),   similar to result of the Guicciardi et al. study that reported any degree of pigment network change in 79% of cases.(13)

In our study, nevi became lighter in 43.9% and darker in 19.7% of cases. The same study reported that pigmentation loss occurred in 82% of nevi but also an increased pigmentation at the periphery with central light brown background happened in most of them.(13)

We reported a decrease in nevus size in 33% of cases that observed more frequently in cases with color change.  Interestingly Guicciardi et al reported increase in size in one case with progressive growth and appearance of globules at the periphery of the lesion. Nevertheless, the histological examination showed features of a compound nevus with slight atypia but not obvious malignant transformation. (13)

We observed asymmetry in 12.1% of nevi after hair removal laser; changing in size was the most related variable with this item and it happened in 75% of asymmetric nevi. Guicciardi et al did not report any asymmetry. Whereas they indicated some other changes like Follicular re-pigmentation or telangiectasia that we did not observed, also they reported crusting in 11% of nevi. (13)

Biography:

Zahra is a medical doctor who graduated from Tehran University of Medical Science about a year ago. She has been interested in research since she started medical school and has worked on basic science and clinical research. Currently, she is a Postdoctoral researcher at the Experimental Medicine Research Center. Zahra's research interests lie in the field of dermatology, specifically in wound healing, itch, and skin inflammation. She is enthusiastic about pursuing her research in these areas and hopes to make significant contributions to the field.

Abstract:

Background: Cholestatic pruritus is a distressful sensation that can cause a massive desire of scratching skin. Despite maximum medication therapy, some patients still experience pruritus. In this study, we evaluated the effect of infliximab on cholestatic pruritus induced in mice by bile duct ligation.

Methods: Twenty-four balb/c mice were randomly assigned to three groups; sham, control, and treatment. The bile duct ligation procedure was performed on mice in the control and treatment groups. After six days, mice in the treatment group received subcutaneous administration of infliximab, and the next day all mice were subjected to the scratching behavior test. Skin and blood samples of mice were collected and evaluated by histopathological, molecular, and biochemical tests.

Results: The scratching behavior has significantly decreased in mice with cholestasis after the administration of infliximab. The levels of TNFα were higher in control mice compared to sham and treatment groups. In addition, expression levels of TNFR2, NF-κB, and IL-31 were decreased in the treatment group compared to the controls, while TNFR1 levels were increased.

Conclusion: Infliximab can block TNFα interaction with receptors and inhibit further inflammatory response. Also, our results suggested that infliximab can suppress IL-31 expression indirectly, which is a well-known cytokine in pruritus pathophysiology. Infliximab can be a potential therapeutic approach in resistant pruritus in cholestatic disorders.

Biography:

I have completed my postgraduation at the age of 27 years from Yonsei university Wonju college of medicine, South Korea. I have published 5 papers in reputed journals. Now I am doing Residency in Dermatology from Kangbuk Samsung Hospital, South Korea.

Abstract:

Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare, low-grade adnexal carcinoma that most commonly presenting on the periorbital skin of elderly women. It was first reported by Flieder et al in 1997 and is recently proposed as an in situ precursor of mucinous carcinoma with neuroendocrine features. EMPSGC and associated mucinous carcinoma likely to behave more indolently than non-endocrine subtype.

A 62-year-old male presented with a year history of an asymptomatic, skin-colored nodule on the left cheek near the edge of lower eyelid. Based on the clinical impression of intradermal nevus, a punch excisional biopsy was performed. Histopathologic findings demonstrated well-circumscribed, dermal nodule comprising bland, uniform tumor cells with stippled chromatin. Also, floating tumor nests were demonstrated within abundant mucin pool. Staining for p63 revealed stromal myoepithelial cells. Immunohistochemistry stains were positive for CK7, CD56, synaptophysin, and chromogranin A, rendering a diagnosis of EMPSGC-associated neuroendocrine primary cutaneous mucinous carcinoma (PCMC). Owing to unclear resection margin, the patient is scheduled to undergo wide excision.

Although rare, dermatologists must be aware of EMPSGC-associated neuroendocrine PCMC as these tumors can be locally destructive and cosmetically disfiguring. To our knowledge, this is the first report in the Korean literature.